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Research - Gastroenterology

Please choose from the following.Some major areas of interest and research for different members of our faculty are the following. The ongoing research projects, recently presented abstracts and published articles within the last 5 years are listed under each topic:

Inflammatory Bowel Disease Research

Currently ongoing Clinical Trials

  1. A Pilot Study to use Methotrexate (MTX) in Steroid-Dependent Pediatric Patient's with Crohn's Disease who are Unresponsive or Intolerant to Azathioprine (AZA) or 6-Mecaptopurine (6-MP)
  2. The Efficacy of Lactobacillus GG in Preventing Relapse in Crohn's Disease

Recently Completed Trials

  1. Complementary Medicine Use in Children and Young Adults with Inflammatory Bowel Disease
  2. Evaluation and Correlations of IBD Serologic Tests with Clinical Diagnosis

Recently Published Abstracts:

  1. Pillai RB, Lin CH, Boeberglu ED, Rabah R, Simpson PH, Tolia V: Increased colonic omithin decarboxylase activity in inflammatory bowel disease in children. J Ped Gastroenterol Nutr, 23:363 (A84), 1996.
  2. Kader HA, Theoret Y, Tolia V. et al. A prospective randomized doubleblind, placebo controlled study to assess the efficacy of intravenous loading of azathioprine in children and adolescents with inflammatory bowel disease. Gastroenterol 118#4,A118,2000
  3. El-Baba M, Peters JM, Lin CH, Sukerek HS, Tolia V. Value of serologic markers in children with inflammatory bowel disease (IBD). Gastrointest Endosc. 51,#4(2)AB259,2000.
  4. Afzal N, Wuerth A, Tolia V., Kemper K, Bousvaros A, Heuschkel R. The use of alternative medicines in children and young adults with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2001

Articles Published:

  1. Tolia V: Spectrum of Perianal Crohn's Disease in Children and Adolescents. Am J Gastroenterol Vol 99, #5, 922-926, 1996.
  2. El-Baba M, Lin CH, Tolia V, Klein M: Outcome after surgical intervention in children with chronic inflammatory bowel disease. Am Surgeon 62 (12): 1014-7, 1996
  3. Ondersma SJ, Lumley Ma, Corlis M, Torjek TM, Tolia V: Adolescents with inflammatory bowel disease: The roles of negative affectivity and hostility in subjective vs objective health. J PediatrPsychol 22:723-738:1997
  4. Pillai RB, Tolia V, Rabah R, Simpson PM, Lin CH. Increased colonic ornithine decarboxylase activity in inflammatory bowel disease in children. Dig. Dis. Sci 44:1565-1570,1999.

Pediatric Motility Research

The following is a list of our recent abstracts and publications

Recently Published Abstracts:

  1. Tolia V, Peters JM. Electrogastrography in infants with gastroesophageal reflux. Gastroenterology, 112:4; A911, 1997.
  2. Hurvitz M, Vargas J, Ament M, Erhart N, Justinich C, Molleston J, Reinstein LJ, Tolia V, Walton JM Bahar R. Evaluation of the use of botulinum toxin in children with achalasia. Gastroenterology 116;#4,Part 2,G0278, 1999.

Recently Published Articles:

  1. Hurwitz M, Vargas J, Ament ME, Tolia V, Molleston J et al. Evaluation of the Use of Botulinum Toxin in Children with Achalasia. J Pediat Gastroenterol Nutr. 30:509-514, 2000
  2. M. Mehra, R.J. Babar, et al., V. Tolia, J. Atkinson. Minimally Invasive Esophagomyotomy for Children with Achalasia. Submitted to JPGN.

Gastroesophageal Reflux Disease (GERD) Research

Currently active studies in evaluation of GERD include:

  1. Evaluation of the Role of Acidic and Non-Acidic Reflux in Recurrent Respiratory and Chronic Ear, Nose and Throat (ENT) Diseases in children by Using Multichannel Intraluminal Impedance (MII) Apparatus
  2. CIS-USA-156 Limited Access Protocol for the Use of Oral Cisapride in the Treatment of Pediatric Patients with Refractory Gastroesophageal Reflux Disease and Other Gastrointestinal Motility Disorders
  3. Histologic Evaluation of Inflammation of the Gastroesophageal Junction in the Pediatric Population
  4. Association of GERD in Children with Chronic ENT Conditions
  5. Combined Intragastric and Intraesophageal Monitoring to Assess the Efficacy of PPI's

Recently Published Abstracts:

  1. Tolia V, Peters JM. Electrogastrography in infants with gastroesophageal reflux. Gastroenterology, 112:4; A911, 1997.
  2. Kaddu, R, Tolia V. Role of saliva scans in neurologically impaired children with orapharyngeal incoordination. J. Pediatr Gastroenterol and Nutr. 85:25;A4, 1997.
  3. Tolia V, Simultaneous intragastric and intraesophageal monitoring in children on proton pump inhibitors. Gastrointest Endosc. 49#4,Part 2,A516, 1999.
  4. Tolia V, Wuerth A, Shashidhar H, Peters JP, Lin CH. A prospective randomized trial of antiregurgitation formula in infants. Gastrointest Endosc. 49#4,Part 2,A514, 1999.
  5. Tolia V, Wuerth A, Thomas R. Are there gender related differences in extended pH monitoring Infants (EPM) parameters in infants. J Pediatr Gastroenterol Nutr 29#4,493,1999.
  6. Gupta SK, Tolia V, Heyman MK et al. Adolescent patients with gastroesophageal reflux disease. Result from a randomized trial of Lansoprazole. Gastroenterology 118,#9,A1242,2000.
  7. Dahshan AH, Patel H, Delaney J, Thomas R, Tolia V. Gastroesophageal reflux disease and Dental erosion in children. Gastrointest Endosc. 51#4(2),AB113,2000.
  8. Gremse D, Tolia V, Pan W, Kane R, Karol M, Chiu Y, Pilmer B, Book L. Pharmacokinetic/Pharmacodynamics of Lansoprazole in Pediatric Patients with Symptomatic Gastroesophageal Reflux Disease. J Pediatr Gastroenterol Nutr 2000.
  9. Levy J, Hayes C, Kern J, Harris, Flores A, Hyams J, Murray R, Tolia V. Does Cisapride Influence Cardiac Rhythm? Results of a US Multicenter. Double-Blind. Placebo Controlled Pediatric Study.J Pediatr Gastroenterol Nutr 2000.
  10. Tolia V, Ferry G, Gumasekaran T, Huang B, Keith R, Book L. Efficacy of Iansoprazole in the Treatment of GERD in children. Am J Gastroenterol Vol 95(9)#122,2000.
  11. Tolia V, Fitzgerald J, Hassall E, Huang B, Pilmer B, Kane R. Safety of Iansoprazole in the Treatment f GERD in children. Am J Gastroenterol Vol 95(9)#123,2000.

Recently Published Articles:

  1. Madani S, Tolia V: Gynecomastia and Galactorrhoea with Metoclopramide in Children. J Clin Gastrnterol 42; 476-480, 1997.
  2. Tolia V: Review of gastroesophageal reflux. Fam Prac Recertif 19; 35-58: 1997
  3. Vijayaratnam V, Simpson P, Lin CH, Tolia V: Role of proximal esophageal acid reflux in infants with respiratory symptoms. Pediatr Pulmonol 27: 231-235; 1999.
  4. Levy J, Hayes C, Kern J, Harris, Flores A, Hyams J, Murray R, Tolia V. Does Cisapride Influence Cardiac Rhythm? Results of a US Multicenter. Double-Blind. Placebo Controlled Pediatric Study. In press with J Pediatr Gastroenterol Nutr.
  5. Dahshan A, Patel M, Delaney J, Thomas R, Wuerth A, Tolia V. Dental erosions in children with gastroesophageal reflux. Submitted

Helicobacter pylori Infection Research

Ongoing Clinical Research Studies:

  1. Antimicrobial Susceptibility of H.pylori in Children with Gastritis
  2. Is Growth of H.pylori Dependent on the Density of Colonization?

Basic Research Studies:

  1. To study the genotypes of H.pylori and their correlation to phenotypic expression
  2. To evaluate oxidative burst activity on neutrophils from children with H.pylori and controls

Recently Published Abstracts:

  1. Shashidhar H, Peters J, Rabah R, Tolia V. Lansoprazole in the treatment of H.pylori infection in children. Gastroenterology 114:4;A 1165, 1998.
  2. Chong SKF, Lou QY, Tolia V, Rosenberg AJ, Rabinowitz S, Elitsur Y, Gold B, Peacock JS. Final report on a multisite investigation of seropositivity for H.pylori in US children. Gastroenterology 114:4;A375, 1998
  3. Chong SKF, Lou QY, Tolia V, Rosenberg AJ, Rabinowitz S, Elitsur Y, Gold B, Peacock JS. Final report on a multisite investigation of seropositivity for H.pylori in US children. J Pediatr Gastroenterol Nutr 26:539; 1998.
  4. Tolia V, Brown W, El-Baba M, Peters J, Lin CH. Antimicrobial susceptibility of Helicobacter pylori from children with gastritis in Michigan. Am J Gastroenterol 94#9,176,1999
  5. Tolia V, Brown W, El-Baba M, Peters J, Lin CH. Helicobacter pylori culture and antimicrobial sensitivity from children in Michigan. J Pediatr Gastroenterol Nutr 2000.

Published Articles:

  1. Shashidhar HS, Peters JM, Lin CH, Thomas R, Tolia V. Lansoprazole based triple therapy for treatment of H.pylori gastritis in children. J Pediat Gastroenterol Nutr. 30;3:276-282,1999.
  2. Madani S, Rabbah R, Tolia V: Comparison of density of H.pylori infection on histology with CLO test in children. Dig Dis Sci 45:1233-1237,2000
  3. Tolia V, Helicobacter pylori in Pediatric Current Gastroenterology reports 1(4);308-313,1999.
  4. Tolia V, Brown W, El-Baba M, Lin CH. Antimicrobial susceptibility of H.pylori from children in Michigan. Pediatr Infect Dis.J 19:1167-1171,2000.

Ontogeny of the Gastrointestinal tract Research Page

Ongoing Studies:

  1. Early Weaning and Gut Development: Role of ODC and Tyr-k (Funded by NIH/NIDDK)
  2. Supplemental Feeding and Pancreatic/Intestinal Development (Funded by Gerber Foundation)

Recently Published Abstracts:

  1. Lin CH, Tolia V, Vijesurier R. Expression of intestinal orhithine decarboxylase antienzyme during postnatal development in rats. Gastroenterology 114:4;A4743, 1998.
  2. Lin CH, Tolia V, Vijesurier R. Expression of intestinal orhithine decarboxylase antienzyme during postnatal development in rats. J Pediatr Gastroenterol Nutr 26:593; 1998
  3. Lin CH, Tolia V, Vijesurier R. Expression of intestinal omithine decarboxylase antizyme during postnatal development in rats. Gastroenterology 114:Al 159, 1998
  4. Lin CH, Tolia V, Vijesurier R. Essential role of polyamine biosynthesis in intestinal growth. Induced by early weaning. J Pediatr Gastroenterol Nutr. 27;#4,A87,1998.
  5. Lin CH, Tolia V, Vijesurier R. Precocious expression of pancreatic amylase induced by food deprivation during postnatal development. Gastroenterology 1999. 116;#4,Part 2,G4965, 1999.
  6. Lin CH, Tolia V, Vijesurier RM. Regulation of intestinal orinthine decarborboxylase (ODC) Expression during postnatal development by ODC antizyme in rats. Gastroenterology 118#4,A292,2000.
  7. Lin CH, Tolia V, Vijesurier RM. Glucocorticoids are important in inducing intestinal ornithine Decarboxylase and its inhibitors, ODC antizyme, during postnatal development in rats. J Pediatr Gastroenterol Nutr 2000.

Recently Published Articles:

  1. Lin CH, Correia L, Tolia K, Gerell MS, Tolia V, Lee PC, Luk GD: Early weaning induces jejunal omithine decarboxylase and cell proliferation in neonatal rats. AJCN 128:1636-1542;1998.
  2. Lyons H., Tolia V, Lin CH.: Induction of Gastric ornithine decarboxylase in early weaning rats. In press with Digestion, 2001.

Useful Links Page

Kids Care - Offers advice for parents and children on health, family life, nutrition and safety
American Academy of Pediatrics (AAP) - Provides information ranging from children's health and safety tips to AAP research and publications
Center for Disease Control and Prevention (CDC) - Offers up-to-date information on all types of health risks for children
The Pediatric Database (PEDBASE) - Contains information and descriptions of over 550 childhood illnesses
PEDINFO- This site is a general resource for all types of info related to Childrens Health
Celiac Resource Center - Contains Information about Celiac Disease

Pediatric Motility Center Page

The Pediatric Gastrointestinal Motility Center at Children's hospital of Michigan is equipped to provide a full array of motility procedures for children of all ages. This is the only center of its kind for pediatric patients in the state of Michigan and is directed under Mohammed El-Baba, M.D. The procedures will include:

  1. Stationary and pull-through esophageal manometry
  2. Botulinum toxin injection for patients with achalasia
  3. Antro-duodenal manometry
  4. Electrogastrography
  5. Multichannel intraluminal impedance studies -the only center in the US for pediatric studies
  6. Anorectal manometry including biofeedback
  7. Colonic manometry
  8. Extended intraesophageal ambulatory manometry
  9. Intraluminal ultrasonography
  10. Barostat studies to assess visceral hyperalgesia

Current ongoing studies include:

  1. Intrasphincteric Botulinum Toxin for the Treatment of Achalasia in Children
  2. Electrogastrogram: A Study of Gastric Motility Parameters in Children
  3. The Safety, Efficacy, and Tolerability of Miralax for Treatment of Chronic Constipation in Children in comparison to Mineral Oil
  4. Review of Children undergoing surgery for biliary dyskinesia

Pediatric Inflammatory Bowel Disease Center

Chronic Inflammatory Bowel Disease (IBD) encompasses a spectrum of disorders, however, the two most common disorders are ulcerative colitis and Crohn's disease. Approximately 25% of patients with IBD have their onset of disease in childhood. This can cause special complications in pediatric patients, of which the most significant is growth failure.

We provide a team approach for the management of children and adolescents with these diseases. Patients with IBD have access to a nutritionist, nurse practitioner, psychologist, social worker and other consultants on an as needed basis so that preventive strategies can be discussed with the families. Excellent clinical care and participation in ongoing pediatric clinical trials puts us in the forefront for providing state of art care for these patients.

An endowed chair for research in Pediatric IBD has also been created at Wayne State University which should enhance our role in contributions to Pediatric IBD research.

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